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The 2019 Gordon Research Conference – the Immunology of Fungal Infections (Mechanisms of Fungal Immunopathology) focuses on leading advances in our understanding of the challenges that fungi impose on the immune system. This meeting – the 5th in its series – has become the must-attend venue for immunologists and medical mycologists to discuss how the immune system responds to the challenge of fungal pathogens, as well as how the fungus responds to the assault of innate and adaptive immune responses.