Conference Calendar
Past Quiz Results
First-ever Study of Mycology Lab Practices in Asia
New Diagnostic Mycology E-learning Course
Antifungal prophylaxis: Whom, what and when
Fereydounia khargensis: A New Opportunistic Yeast Reported from Malaysia
9 Years of MMTN: Improving Fungal Disease Management in Asia Pacific
Echinocandins: Clinicians' Guide
Fungemia blood culture media
Deep dermatophytosis
AFWG Education Module 4: Is Antifungal Susceptibility Testing Useful for Clinical Management?
AFWG Education Module 5: TDM of Antifungal Agents - Essential or Optional?
AFWG Education Module 6: Antifungal Stewardship
Itraconazole: A Quick Guide for Clinicians
Evolving Fungal Landscape in Asia
Laboratory Diagnosis of Pythiosis
ICMR Issues C. auris Advisory
Strengths and Limitations of Imaging for Diagnosis of IFI
Candidemia: Lessons Learned from Asian Studies for Intervention
Pivotal Asian Invasive Mold Study
Mycetoma in Asia: Still veiled in mystery
New Antifungal Agents
A challenging case: A crisis unfolds
Making Precise Diagnoses: Experience from the Laboratory Skills Enhancement Course
A challenging case: A 68-year-old man with nasal and palatal ulcers
AFWG Online Education Module 3: Optimizing Dosing in IFI Management
AFWG Online Education Module 2: Antifungal Prophylaxis in Solid Organ Transplantation
AFWG Education Module 1: The Value of Clinical Mycology Laboratories
Cryptococcosis in HIV and non-HIV infected patients
Human Pythiosis
AFWGOnline Privacy Policy has been Updated
Management of fungal infections in high-risk patients
Striving for Perfection: Experience from the Laboratory Foundation Training Course
Know your fungal landscape in Vietnam
Recent Advances of Fungal Diagnostics in Asian Laboratories
Deep Dermatophytosis: A Case Report
Management of cryptococcosis and talaromycosis
A challenging case: A 49-year-old woman with sarcoidosis
Emerging yeast infections in Asia
Outbreak of Superbug Candida auris: Asian Scenario and Interventions
Championing Medical Mycology: Thoughts on the AFWG Laboratory Skills Enhancement Course
Mucormycosis and Pythiosis – New Insights
AML and the high risk of multiple infectious complications
Do We Need Modification of Recent IDSA & ECIL Guidelines while Managing Patients in Asia?
A hospital’s experience with candidemia and empirical therapy
Fungal Academy 2015
Fluconazole in 2015
Fungal isolation protocol
Influencing Aspergillus
Fungal Asthma
Laboratory Diagnosis of IPA
Educational Organizations
Literature Updates



Share this

this page

Aspergillus, of which A. fumigatus is the most commonly isolated species, is an important etiology of life-threatening fungal infections in the immunocompromised population, including those with prolonged neutropenia, transplant recipients and HIV-afflicted patients with advanced disease. As cited in the 2008 Infectious Diseases Society of America (IDSA) treatment guidelines, aspergillosis causes patient afflictions that are classically defined as invasive (respiratory, central nervous system and other organs), saprophytic (otomycosis and pulmonary aspergilloma) or allergic (sinusitis and allergic bronchopulmonary aspergillosis [ABPA]).1

Aspergillus fumigatus under (A) brightfield microscopy, with lactophenol cotton blue staining, and (B) scanning electron microscopy (x1,000)

Images courtesy of Dr Ariya Chindamporn
Images courtesy of Dr Ariya Chindamporn


Proven aspergillosis requires histopathological evidence of infection and a positive culture of a specimen from a normally sterile site. Probable aspergillosis requires fulfillment of criteria within 3 categories: host factors, clinical manifestations (symptoms, signs and radiological features), and microbiological evidence. Therefore, proven or probable infection requires the recovery of Aspergillus. However, there are 2 exceptions cited in the IDSA guidelines.1 The first exception includes the fairly frequent occurrence of histopathological demonstration of hyphae consistent with Aspergillus species in patients with negative culture results. The other exception is the use of a surrogate non–culture-based method (ie, a positive galactomannan assay or (1-3)-β-D-glucan assay result and radiologically compatible CT findings) in an immunocompromised host with clinical findings of infection that constitute the definition of probable invasive aspergillosis.


  1. Walsh TJ, et al. Clin Infect Dis 2008;46:327-360.

This field is required. Please enter your email address.
Thank you for signing up for the AFWG newsletter.
You have previously subscribed for AFWG newsletter.